There are multiple related conditions associated with hEDS/HSD. We encourage individuals and their primary care practitioners to consider printing off a copy of this list and highlighting the conditions that you have been diagnosed with for the conversation if you have either hEDS/HSD. Please also remember that even in identical twins, symptoms can present differently and in severity in families. To print a copy click here.

Allergic diseases

• Food allergies
• Mast Cell diseases
• Sjogren’s Syndrome

Cardiovascular

• POTS: Postural Orthostatic
• Tachycardia
• Mitrovalve prolapse
• Aortic root dilation
• Dysautonomia

Dermatologic

• Rashes
• Poor wound healing

Fatigue

• Chronic fatigue syndrome
• 38%
• Exercise intolerance
• Postexercise malaise (PEM)

Gastrointestinal

• Abdominal: pain (< half)
• Celiac disease (5-16%)
• Constipation
• Crohn’s disease
• Dysmotility
• Dysphagia
• Eosinophilic esophagitis
• Functional dyspepsia
• Gastrointestinal reflux disease
• Gastroparesis
• Hiatal hernia
• Irritable bowel syndrome
• Pelvic floor disorders
• Pelvic organ prolapse
• Nausea

Gynecologic / Men’s Health

• Pelvic pain
• Dysmenorrhea
• Urinary stress and/or urge incontinence
• Neurogenic bladder

Hematological

• Thrombocytopenia
• Thromboembolism
• Mastocytosis
• Mast Cell Activation Syndrome

Musculoskeletal

• Temporomandibular joint disorders
• Compression disorders
• Osteopenia/osteoporosis
• Osteoarthritis
• Fibromyalgia-40%
• Pain – 100%

Neurodivergence

• Autism
• ADHD
• Tic disorder

Neurological

• Migraine headache
• Tension-type headache
• Dystonia
• Decreased school performance
• Brain fog/cognitive difficulties
• Low mood
• Difficulty concentrating
• Memory problems
• Somatization
• Neurogenic bladder
• Atlanto-axial instability
• Chiari malformation
• Craniocervical instability
• CSF disorders (shunts)

Ophthalmology

• Retina detachment

Otolaryngology

• Swallowing disorder

Psychiatric

• Anxiety
• Depression
• Insomnia
• Eating disorders

And many more as research continues.